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Dual HIV-1 infection associated with rapid disease progression.
| Title | Dual HIV-1 infection associated with rapid disease progression. |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | Gottlieb, GS, Nickle, DC, Jensen, MA, Wong, KG, Grobler, J, Li, F, Liu, S-L, Rademeyer, C, Learn, GH, Karim, SSAbdool, Williamson, C, Corey, L, Margolick, JB, Mullins, JI |
| Journal | Lancet |
| Volume | 363 |
| Issue | 9409 |
| Pagination | 619-22 |
| Date Published | 2004 Feb 21 |
| ISSN | 1474-547X |
| Keywords | Acquired Immunodeficiency Syndrome, Adult, Branched DNA Signal Amplification Assay, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Disease Progression, Female, HIV Infections, HIV-1, Humans, Male, Retrospective Studies, Reverse Transcriptase Polymerase Chain Reaction, RNA, Viral, Superinfection, Viral Load |
| Abstract | Infection with two strains of HIV-1 has implications for understanding HIV transmission and vaccine development; however, frequency and pathogenic consequences of dual infection are unknown. We assessed 64 patients for dual infection with heteroduplex mobility assay, viral sequencing, and phylogenetic methods. HIV disease outcomes were available in 34 patients. Five of these with AIDS endpoints had dual infection with HIV-1: four were cases of coinfection and one was superinfection. In all five, time from seroconversion to clinical AIDS or to CD4+ T-cell count less than 200 cells per microL was very rapid (<3.4 and <3.1 years, respectively). Our findings should prompt larger studies to assess the effect of dual infection at the population level. |
| DOI | 10.1016/S0140-6736(04)15596-7 |
| Alternate Journal | Lancet |
| PubMed ID | 14987889 |
