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Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells.
Title | Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Pepper, M, Linehan, JL, Pagán, AJ, Zell, T, Dileepan, T, P Cleary, P, Jenkins, MK |
Journal | Nat Immunol |
Volume | 11 |
Issue | 1 |
Pagination | 83-9 |
Date Published | 2010 Jan |
ISSN | 1529-2916 |
Keywords | Amino Acid Sequence, Animals, Antigens, CD27, CD4-Positive T-Lymphocytes, Cell Differentiation, Cell Line, Cell Proliferation, Cell Survival, Clone Cells, Flow Cytometry, Histocompatibility Antigens Class II, Host-Pathogen Interactions, Immunologic Memory, Interferon-gamma, Interleukin-17, Listeria monocytogenes, Listeriosis, Mice, Mice, Inbred C57BL, Mice, Inbred Strains, Proto-Oncogene Proteins c-bcl-2, Receptors, Interleukin-15, T-Lymphocytes, Helper-Inducer, Th1 Cells, Time Factors |
Abstract | We used a sensitive method based on tetramers of peptide and major histocompatibility complex II (pMHCII) to determine whether CD4(+) memory T cells resemble the T helper type 1 (T(H)1) and interleukin 17 (IL-17)-producing T helper (T(H)17) subsets described in vitro. Intravenous or intranasal infection with Listeria monocytogenes induced pMHCII-specific CD4(+) naive T cells to proliferate and produce effector cells, about 10% of which resembled T(H)1 or T(H)17 cells, respectively. T(H)1 cells were also present among the memory cells that survived 3 months after infection, whereas T(H)17 cells disappeared. The short lifespan of T(H)17 cells was associated with small amounts of the antiapoptotic protein Bcl-2, the IL-15 receptor and the receptor CD27, and little homeostatic proliferation. These results suggest that T(H)1 cells induced by intravenous infection are more efficient at entering the memory pool than are T(H)17 cells induced by intranasal infection. |
DOI | 10.1038/ni.1826 |
Alternate Journal | Nat. Immunol. |
PubMed ID | 19935657 |
PubMed Central ID | PMC2795784 |
Grant List | AI27998 / AI / NIAID NIH HHS / United States AI39614 / AI / NIAID NIH HHS / United States AI66016 / AI / NIAID NIH HHS / United States P01 AI035296-170001 / AI / NIAID NIH HHS / United States R01 AI039614-13 / AI / NIAID NIH HHS / United States R37 AI027998-20 / AI / NIAID NIH HHS / United States T32-AI07313 / AI / NIAID NIH HHS / United States T32-CA9138 / CA / NCI NIH HHS / United States |