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Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish.
Title | Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish. |
Publication Type | Journal Article |
Year of Publication | 2007 |
Authors | Clay, H, J Davis, M, Beery, D, Huttenlocher, A, Lyons, SE, Ramakrishnan, L |
Journal | Cell Host Microbe |
Volume | 2 |
Issue | 1 |
Pagination | 29-39 |
Date Published | 2007 Jul 12 |
ISSN | 1934-6069 |
Keywords | Animals, Embryo, Nonmammalian, Fish Diseases, Macrophages, Mycobacterium Infections, Nontuberculous, Mycobacterium marinum, Zebrafish |
Abstract | In tuberculosis, infecting mycobacteria are phagocytosed by macrophages, which then migrate into deeper tissue and recruit additional cells to form the granulomas that eventually contain infection. Mycobacteria are exquisitely adapted macrophage pathogens, and observations in the mouse model of tuberculosis have suggested that mycobacterial growth is not inhibited in macrophages until adaptive immunity is induced. Using the optically transparent and genetically tractable zebrafish embryo-Mycobacterium marinum model of tuberculosis, we have directly examined early infection in the presence and absence of macrophages. The absence of macrophages led rapidly to higher bacterial burdens, suggesting that macrophages control infection early and are not an optimal growth niche. However, we show that macrophages play a critical role in tissue dissemination of mycobacteria. We propose that residence within macrophages represents an evolutionary trade-off for pathogenic mycobacteria that slows their early growth but provides a mechanism for tissue dissemination. |
DOI | 10.1016/j.chom.2007.06.004 |
Alternate Journal | Cell Host Microbe |
PubMed ID | 18005715 |
PubMed Central ID | PMC3115716 |
Grant List | K22 F007309 / / PHS HHS / United States R01 AI036396 / AI / NIAID NIH HHS / United States R01 AI036396-19 / AI / NIAID NIH HHS / United States R01 AI054503-09 / AI / NIAID NIH HHS / United States R01 AI54503 / AI / NIAID NIH HHS / United States R01 GM074827 / GM / NIGMS NIH HHS / United States T32 GM07270 / GM / NIGMS NIH HHS / United States |