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Colony-stimulating factors in the prevention and management of infectious diseases.
Title | Colony-stimulating factors in the prevention and management of infectious diseases. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Page, AV, W Liles, C |
Journal | Infect Dis Clin North Am |
Volume | 25 |
Issue | 4 |
Pagination | 803-17 |
Date Published | 2011 Dec |
ISSN | 1557-9824 |
Keywords | Communicable Diseases, Granulocyte Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor, Humans, Macrophage Colony-Stimulating Factor, Monocytes, Neoplasms, Neutropenia, Neutrophils |
Abstract | Colony-stimulating factors (CSFs) are attractive adjunctive anti-infective therapies. Used to enhance innate host defenses against microbial pathogens, the myeloid CSFs increase absolute numbers of circulating innate immune effector cells by accelerating bone marrow production and maturation, or augment the function of those cells through diverse effects on chemotaxis, phagocytosis, and microbicidal functions. This article summarizes the evidence supporting the accepted clinical uses of the myeloid CSFs in patients with congenital or chemotherapy-induced neutropenia, and presents an overview of proposed and emerging uses of the CSFs for the prevention and treatment of infectious diseases in other immunosuppressed and immunocompetent patient populations. |
DOI | 10.1016/j.idc.2011.07.007 |
Alternate Journal | Infect. Dis. Clin. North Am. |
PubMed ID | 22054757 |