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Characteristics of HIV-2 and HIV-1/HIV-2 Dually Seropositive Adults in West Africa Presenting for Care and Antiretroviral Therapy: The IeDEA-West Africa HIV-2 Cohort Study.
| Title | Characteristics of HIV-2 and HIV-1/HIV-2 Dually Seropositive Adults in West Africa Presenting for Care and Antiretroviral Therapy: The IeDEA-West Africa HIV-2 Cohort Study. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Ekouevi, DK, Balestre, E, Coffie, PA, Minta, D, Messou, E, Sawadogo, A, Minga, A, Sow, PSalif, Bissagnene, E, Eholie, SP, Gottlieb, GS, Dabis, F, Zannou, DMarcel, Ahouada, C, Akakpo, J, Ahomadegbé, C, Bashi, J, Gougounon-Houéto, A, Azon-Kouanou, A, Houngbé, F, Koumakpaï, S, Alihonou, F, d'Almeida, M, Hodonou, I, Hounhoui, G, Sagbo, G, Tossa-Bagnan, L, Adjide, H, Drabo, J, Bognounou, R, Dienderé, A, Traore, E, Zoungrana, L, Zerbo, B, Sawadogo, ABruno, Zoungrana, J, Héma, A, Soré, I, Bado, G, Tapsoba, A, Yé, D, Kouéta, F, Ouedraogo, S, Ouédraogo, R, Hiembo, W, Gansonré, M, Messou, E, Gnokoro, JCharles, Koné, M, Kouakou, GMartial, Bosse, CAmani, Brou, K, Assi, AIsidore, Chenal, H, Hawerlander, D, Soppi, F, Minga, A, Abo, Y, Bomisso, G, Eholié, SPaul, Amego, MDeborah No, Andavi, V, Diallo, Z, Ello, F, Tanon, AKoffi, Koule, SOlivier, Anzan, KCharles, Guehi, C, Aka, EAddi, Issouf, KLadji, Kouakou, J-C, N'gbeche, M-S, Touré, P, Avit-Edi, D, Kouakou, K, Moh, M, Yao, VAndoblé, Folquet, MAmorissani, Dainguy, M-E, Kouakou, C, Méa-Assande, VTanoh, Oka-Berete, G, Zobo, N, Acquah, P, Kokora, M-B, Eboua, TFrançois, Timité-Konan, M, Ahoussou, LDiecket, Assouan, JKebé, Sami, MFlora, Kouadio, C, Renner, L, Goka, B, Welbeck, J, Sackey, A, Owiafe, SNtiri, Wejse, C, Da Silva, ZJosé, Paulo, J, Rodrigues, A, da Silva, D, Medina, C, Oliviera-Souto, I, Ostergaard, L, Laursen, A, Sodemann, M, Aaby, P, Fomsgaard, A, Erikstrup, C, Eugen-Olsen, J, Maïga, MY, Diakité, FFofana, Kalle, A, Katile, D, Traore, HAlassane, Minta, D, Cissé, T, Dembelé, M, Doumbia, M, Fomba, M, Kaya, ASoukho, Traoré, AM, Traoré, H, Toure, AAbathina, Dicko, F, Sylla, M, Berthé, A, Traoré, HCoulibaly, Koïta, A, Koné, N, N'diaye, C, Coulibaly, STouré, Traoré, M, Traoré, N, Charurat, M, Ajayi, S, Dapiap, S, Igbinoba, F, Benson, O, Adebamowo, C, James, J, Osakede, P, Olasode, J, Sow, PSalif, Diop, B, Manga, NMagloire, Tine, JMalick, Sy, HSignate, Ba, A, Diagne, A, Dior, H, Faye, M, Gueye, RDiagne, Mbaye, ADiack, Patassi, A, Kotosso, A, Kariyare, BGoilibe, Gbadamassi, G, Komi, A, Mensah-Zukong, KEdem, Pakpame, P, Lawson-Evi, AKoko, Atakouma, Y, Takassi, E, Djeha, A, Ephoévi-Gah, A, Djibril, SEl-Hadj, Dabis, F, Bissagnene, E, Arrivé, E, Coffie, P, Ekouevi, D, Jaquet, A, Leroy, V, Lewden, C, Sasco, A, Azani, J-C, Allou, G, Balestre, E, Bohossou, F, Karcher, S, Gonsan, JMahan, Le Carrou, J, Lenaud, S, Nchot, C, Malateste, K, Yao, ARoseamonde, Siloué, B, Clouet, G, Djetouan, H, Doring, A, Kouakou, A, Rabourdin, E, Rivenc, J, Anglaret, X, Ba, B, Essanin, JBosco, Ciaranello, A, Datté, S, Desmonde, S, Diby, J-SElvis, Gottlieb, GS, Horo, AGninlgninr, Kangah, SN'zoré, Malvy, D, Meless, D, Mounkaila-Harouna, A, Ndondoki, C, Shiboski, C, Thiébaut, R |
| Corporate Authors | IeDEA West Africa collaboration |
| Journal | PLoS One |
| Volume | 8 |
| Issue | 6 |
| Pagination | e66135 |
| Date Published | 2013 |
| ISSN | 1932-6203 |
| Abstract | BACKGROUND: HIV-2 is endemic in West Africa. There is a lack of evidence-based guidelines on the diagnosis, management and antiretroviral therapy (ART) for HIV-2 or HIV-1/HIV-2 dual infections. Because of these issues, we designed a West African collaborative cohort for HIV-2 infection within the framework of the International epidemiological Databases to Evaluate AIDS (IeDEA). METHODS: We collected data on all HIV-2 and HIV-1/HIV-2 dually seropositive patients (both ARV-naive and starting ART) and followed-up in clinical centres in the IeDEA-WA network including a total of 13 clinics in five countries: Benin, Burkina-Faso Côte d'Ivoire, Mali, and Senegal, in the West Africa region. RESULTS: Data was merged for 1,754 patients (56% female), including 1,021 HIV-2 infected patients (551 on ART) and 733 dually seropositive for both HIV-1 and HIV 2 (463 on ART). At ART initiation, the median age of HIV-2 patients was 45.3 years, IQR: (38.3-51.7) and 42.4 years, IQR (37.0-47.3) for dually seropositive patients (p = 0.048). Overall, 16.7% of HIV-2 patients on ART had an advanced clinical stage (WHO IV or CDC-C). The median CD4 count at the ART initiation is 166 cells/mm(3), IQR (83-247) among HIV-2 infected patients and 146 cells/mm(3), IQR (55-249) among dually seropositive patients. Overall, in ART-treated patients, the CD4 count increased 126 cells/mm(3) after 24 months on ART for HIV-2 patients and 169 cells/mm(3) for dually seropositive patients. Of 551 HIV-2 patients on ART, 5.8% died and 10.2% were lost to follow-up during the median time on ART of 2.4 years, IQR (0.7-4.3). CONCLUSIONS: This large multi-country study of HIV-2 and HIV-1/HIV-2 dual infection in West Africa suggests that routine clinical care is less than optimal and that management and treatment of HIV-2 could be further informed by ongoing studies and randomized clinical trials in this population. |
| DOI | 10.1371/journal.pone.0066135 |
| Alternate Journal | PLoS ONE |
| PubMed ID | 23824279 |
