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Cellular routes of invasion by enteropathogens.
Title | Cellular routes of invasion by enteropathogens. |
Publication Type | Journal Article |
Year of Publication | 2000 |
Authors | Vazquez-Torres, A, Fang, FC |
Journal | Curr Opin Microbiol |
Volume | 3 |
Issue | 1 |
Pagination | 54-9 |
Date Published | 2000 Feb |
ISSN | 1369-5274 |
Keywords | Animals, Antigens, CD18, Enterobacteriaceae, Enterobacteriaceae Infections, Epithelial Cells, Humans, Intestinal Mucosa, Mice, Peyer's Patches |
Abstract | The cellular pathways of infection utilized by pathogenic enteric bacteria have important implications for their clinical manifestations. Yersinia reaches Peyer's patches via M cells and uses plasmid-encoded factors to resist phagocytic cells. Shigella also translocates via M cells and incapacitates phagocytes, but subsequently re-enters the epithelium basolaterally to elicit an acute inflammatory response. Salmonella has recently been shown to both colonize Peyer's patches via M cells and independently disseminate to extraintestinal sites via CD18-expressing phagocytes. M cell-mediated entry can lead to gastroenteritis and mucosal antibody production, while systemic dissemination can result in septicemia and elicitation of systemic immune responses. |
Alternate Journal | Curr. Opin. Microbiol. |
PubMed ID | 10679413 |
Grant List | AI39577 / AI / NIAID NIH HHS / United States AI44486 / AI / NIAID NIH HHS / United States |