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Behavior of parasite-specific effector CD8+ T cells in the brain and visualization of a kinesis-associated system of reticular fibers.
Title | Behavior of parasite-specific effector CD8+ T cells in the brain and visualization of a kinesis-associated system of reticular fibers. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Wilson, EH, Harris, TH, Mrass, P, John, B, Tait, ED, Wu, GF, Pepper, M, E Wherry, J, Dzierzinski, F, Roos, D, Haydon, PG, Laufer, TM, Weninger, W, Hunter, CA |
Journal | Immunity |
Volume | 30 |
Issue | 2 |
Pagination | 300-11 |
Date Published | 2009 Feb 20 |
ISSN | 1097-4180 |
Keywords | Animals, CD8-Positive T-Lymphocytes, Cell Movement, Central Nervous System, Mice, Rats, Toxoplasma, Toxoplasmosis, Cerebral |
Abstract | To understand lymphocyte behavior in the brain, we used two-photon microscopy to visualize effector CD8(+) T cells during toxoplasmic encephalitis. These cells displayed multiple behaviors with two distinct populations of cells apparent: one with a constrained pattern of migration and one with a highly migratory subset. The proportion of these populations varied over time associated with changes in antigen availability as well as T cell expression of the inhibitory receptor PD1. Unexpectedly, the movement of infiltrating cells was closely associated with an infection-induced reticular system of fibers. This observation suggests that, whereas in other tissues pre-existing scaffolds exist that guide lymphocyte migration, in the brain specialized structures are induced by inflammation that guide migration of T cells in this immune-privileged environment. |
DOI | 10.1016/j.immuni.2008.12.013 |
Alternate Journal | Immunity |
PubMed ID | 19167248 |
PubMed Central ID | PMC2696229 |
Grant List | AI41158 / AI / NIAID NIH HHS / United States R01 AI041158-11 / AI / NIAID NIH HHS / United States R01 AI041158-14 / AI / NIAID NIH HHS / United States |