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Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes.
Title | Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Sapkota, BR, Macdonald, M, Berrington, WR, E Misch, A, Ranjit, C, M Siddiqui, R, Kaplan, G, Hawn, TR |
Journal | Hum Immunol |
Volume | 71 |
Issue | 10 |
Pagination | 992-8 |
Date Published | 2010 Oct |
ISSN | 1879-1166 |
Keywords | Adult, DNA Mutational Analysis, Erythema Nodosum, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Leprosy, Male, Mannose-Binding Lectin, Nepal, Polymorphism, Genetic, Promoter Regions, Genetic, Receptors, Calcitriol, Tumor Necrosis Factor-alpha |
Abstract | Although genetic variants in tumor necrosis factor (TNF), mannose binding lectin (MBL), and the vitamin D receptor (VDR) have been associated with leprosy clinical outcomes, these findings have not been extensively validated. We used a case-control study design with 933 patients in Nepal, which included 240 patients with type I reversal reaction (RR), and 124 patients with erythema nodosum leprosum (ENL) reactions. We compared genotype frequencies in 933 cases and 101 controls of seven polymorphisms, including a promoter region variant in TNF (G -308A), three polymorphisms in MBL (C154T, G161A and G170A), and three variants in VDR (FokI, BsmI, and TaqI). We observed an association between TNF -308A and protection from leprosy with an odds ratio of 0.52 (95% confidence interval = 0.29-0.95, p = 0.016). MBL polymorphism G161A was associated with protection from lepromatous leprosy (odds ratio = 0.33, 95% confidence interval = 0.12-0.85, p = 0.010). VDR polymorphisms were not associated with leprosy phenotypes. These results confirm previous findings of an association of TNF -308A with protection from leprosy and MBL polymorphisms with protection from lepromatous leprosy. The statistical significance was modest and will require further study for conclusive validation. |
DOI | 10.1016/j.humimm.2010.07.001 |
Alternate Journal | Hum. Immunol. |
PubMed ID | 20650301 |