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Association between peripheral γδ T-cell profile and disease progression in individuals infected with HIV-1 or HIV-2 in West Africa.
Title | Association between peripheral γδ T-cell profile and disease progression in individuals infected with HIV-1 or HIV-2 in West Africa. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Zheng, NN, McElrath, JM, Sow, PSalif, Mesher, A, Hawes, SE, Stern, J, Gottlieb, GS, De Rosa, SC, Kiviat, NB |
Journal | J Acquir Immune Defic Syndr |
Volume | 57 |
Issue | 2 |
Pagination | 92-100 |
Date Published | 2011 Jun 1 |
ISSN | 1944-7884 |
Keywords | Adaptive Immunity, Adult, Biological Markers, Disease Progression, Female, HIV Infections, HIV-1, HIV-2, Humans, Immunity, Innate, Immunologic Memory, Immunophenotyping, Longitudinal Studies, Lymphocyte Activation, Lymphocyte Count, Male, Receptors, Antigen, T-Cell, gamma-delta, RNA, Viral, Senegal, T-Lymphocyte Subsets, Viral Load |
Abstract | BACKGROUND: Human gammadelta (γδ) T cells play an important role in protective immunity in HIV-1 and simian immunodeficiency virus infection; their role in HIV-2 infection is unknown. OBJECTIVE: To determine the role of γδ T cells in control of plasma viral load and CD4 T-cell count in HIV-1 and HIV-2 infections in West Africa. METHODS: Thirty HIV-1 and 25 HIV-2 treatment-naive chronically infected individuals, and 20 HIV-seronegative individuals from Senegal were studied using multiparametric flow cytometry to investigate the frequencies and phenotypes of peripheral γδ T cells. γδ T-cell parameters and correlates of HIV disease progression were assessed. RESULTS: : We observed an expansion of Vδ1 T-cell populations in both HIV-1 and HIV-2 infection. However, unlike HIV-1 infection, no significant contraction of the frequency of total Vδ2 T cells was observed in HIV-2 infection. Significantly lower frequencies of CD4Vδ2 T cells were observed in HIV-2-infected individuals. Furthermore, frequencies of CD28CD45RO and CD27CD28CD45RO Vδ2 T cell were low in HIV-1-infected individuals. Vδ2 T-cell activation levels were elevated in both HIV-1-infected and HIV-2-infected individuals. The frequency of HLA-DRCD38-activated Vδ1 and Vδ2 T cells was associated with a decline in CD4 T-cell counts and increased viral load in both HIV-1 and HIV-2 infection. CONCLUSIONS: Although maintaining the normal frequency of total Vδ2 T cells, HIV-2 infection reduces the frequency of CD4Vδ2 T cells and alters the frequencies of subsets of Vδ1 T cells. Both HIV-1 and HIV-2 infection induce γδ T-cell activation, and this activation is associated with the disease progression. |
DOI | 10.1097/QAI.0b013e318215a877 |
Alternate Journal | J. Acquir. Immune Defic. Syndr. |
PubMed ID | 21423026 |