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Home ยป Antibody response to a Babesia bigemina rhoptry-associated protein 1 surface-exposed and neutralization-sensitive epitope in immune cattle.

Antibody response to a Babesia bigemina rhoptry-associated protein 1 surface-exposed and neutralization-sensitive epitope in immune cattle.

TitleAntibody response to a Babesia bigemina rhoptry-associated protein 1 surface-exposed and neutralization-sensitive epitope in immune cattle.
Publication TypeJournal Article
Year of Publication1994
AuthorsUshe, TC, Palmer, GH, Sotomayor, L, Figueroa, JV, Buening, GM, Perryman, LE, McElwain, TF
JournalInfect Immun
Volume62
Issue12
Pagination5698-701
Date Published1994 Dec
ISSN0019-9567
KeywordsAnimals, Antibodies, Monoclonal, Antibodies, Protozoan, Antigens, Protozoan, Babesia, Babesiosis, Cattle, Cattle Diseases, Epitopes, Membrane Proteins, Neutralization Tests, Protozoan Proteins, Species Specificity, Vaccination
Abstract

Protective immunity against Babesia bigemina is hypothesized to involve antibodies directed against merozoite surface-exposed epitopes. Levels of antibody against a rhoptry-associated protein 1 (RAP-1) B-lymphocyte epitope, defined by surface-reactive and inhibitory monoclonal antibodies, in immune cattle sera were determined. All cattle produced antibodies to the epitope; however, there was limited correlation between immune protection induced by infection or RAP-1 immunization and the level of antibody to the neutralization-sensitive B-lymphocyte epitope examined.
Alternate JournalInfect. Immun.
PubMed ID7525490
PubMed Central IDPMC303324