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Home ยป The alternative sigma factor katF (rpoS) regulates Salmonella virulence.

The alternative sigma factor katF (rpoS) regulates Salmonella virulence.

TitleThe alternative sigma factor katF (rpoS) regulates Salmonella virulence.
Publication TypeJournal Article
Year of Publication1992
AuthorsFang, FC, Libby, SJ, Buchmeier, NA, Loewen, PC, Switala, J, Harwood, J, Guiney, DG
JournalProc Natl Acad Sci U S A
Volume89
Issue24
Pagination11978-82
Date Published1992 Dec 15
ISSN0027-8424
KeywordsAnimals, Base Sequence, Catalase, DNA Damage, DNA Repair, Gene Expression Regulation, Bacterial, Genes, Bacterial, Hydrogen-Ion Concentration, Methyl Methanesulfonate, Mice, Molecular Sequence Data, Oligodeoxyribonucleotides, Polymerase Chain Reaction, Salmonella Infections, Animal, Salmonella typhimurium, Sigma Factor
Abstract

Nutrient limitation is a critical signal in Salmonella virulence gene regulation. The katF (rpoS) gene mediates the expression of the Salmonella spv plasmid virulence genes during bacterial starvation. A katF Salmonella mutant has increased susceptibility to nutrient deprivation, oxidative stress, acid stress, and DNA damage, conditions which are relevant to the intraphagosomal environment of host macrophages. Moreover, the katF mutant has significantly reduced virulence in mice. katF encodes an alternative sigma factor of RNA polymerase which coordinately regulates Salmonella virulence.
Alternate JournalProc. Natl. Acad. Sci. U.S.A.
PubMed ID1465428
PubMed Central IDPMC50681
Grant List5 T32 AI07036 / AI / NIAID NIH HHS / United States
AM35108 / AM / NIADDK NIH HHS / United States
DK01408-05 / DK / NIDDK NIH HHS / United States