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Naeha Subramanian, Ph.D.

Institute for Systems Biology | 401 Terry Ave N. Seattle, WA 98109
(206) 732-1226

Lab Staff

Leah Rommereim, Postdoctoral Fellow
Ajay Akhade, Postdoctoral Fellow
Henry Hampton, Postdoctoral Fellow
Clifford Rostomily, Research Associate
Eoin Parsons, Intern
Naeha Subramanian, Ph.D.
Assistant Professor, Institute for Systems Biology, Seattle, WA | Affiliate Assistant Professor, Department of Immunology | Affiliate Assistant Professor, Department of Global Health University of Washington, Seattle, WA | Faculty Member, Interdisciplinary Program in Pathobiology | Faculty Member, Molecular and Cellular Biology Program University of Washington

The Subramanian lab studies innate immune responses mediated by a class of intracellular sensors of pathogens and danger called the NOD-like receptors (NLRs) and their role in immune disease. A key aspect of our work is using unbiased systems biology approaches for combining information from multiple levels such as genes, proteins and whole cells to identify NLR signaling pathways and their regulation. Another major focus is on investigating the activation of inflammasomes, which are signaling complexes formed by some NLRs, and the role of sub-cellular structures such as mitochondria in regulation of inflammasome function. Our goal is to discern novel functions and regulatory mechanisms of NLRs, and ultimately harness this information for therapeutic modulation of NLR function in immune diseases.