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Justin J. Taylor, Ph.D.

Fred Hutch | VIDD | 1100 Fairview Ave Seattle, WA 98109
(206) 667-7794

Lab Staff

Blair DeBuysscher, PhD. Postdoc
Tara Bancroft, PhD. Postdoc
Jim Boonyaratanakornkit, MD PhD, Medical Fellow
Ali Schwartz, Research Technician
Carson Harms, MS, Research Technician
Justin J. Taylor, Ph.D.
Assistant Member, Immunology and Vaccine Development Program, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA

Most vaccines provide protection by inducing the production of antibodies that can bind to a pathogen and block infection. Unfortunately, there are many dangerous viruses in which the development of a vaccine has been elusive despite decades of intense research. These failures highlight gaps in knowledge about the type of cell that can produce antibodies, the B cell. The Taylor lab aims to inform vaccine design by gaining a deeper understanding about the mechanisms limiting the generation of a protective B cell response. To do this, we study B cell responses in humans and murine models beginning with the rare pathogen-specific “naive” B cells present prior to the vaccination using an enrichment method we recently developed. These approaches allow for the phenotypic and functional analysis of naive and activated B cells that target protective epitopes on candidate vaccine antigens such as HIV Envelope.

Associated Research: