David M. Koelle, M.D.

My research interests are in the areas of virology and immunology, with spillover into diverse areas including viral oncogenesis, tumor immunotherapy, practical vaccinology issues such as adjuvants and delivery systems, and immune-mediated adverse drug reactions. The core skill in my lab is the refined dissection of the human T-cell response to large-genome pathogens, with a newer focus on T-cell receptor expression and biology. Our deepest experience is with HSV-1, HSV-2, and VZV, where our work has spanned from candidate vaccine discovery to pre-clinical models to immunogenicity testing for clinical trials. The lab is located in the Center for Emerging and Re-Emerging Infectious Diseases (CERID) in the UW SLU3.1 building. I have affiliate appointments at both FCHRC and BRI that catalyze ongoing collaborations.